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A-Potene

$8.99

INDICATIONS

A-Potene™ may be a useful dietary supplement for those who wish to increase their daily beta-carotene

intake.

FORMULA (#7993)

Each Softgel Contains:

Vitamin A (as 100% Beta-Carotene) ............................................................... 25,000 IU

SUGGESTED USE

Adults take 1 softgel daily or as directed by healthcare professional.

SIDE EFFECTS

No adverse side effects have been reported.

STORAGE

Store in a cool, dry place, away from direct light. Keep out of reach of children.A-Potene™

2

PRODUCT DATA DOUGLAS LABORATORIES® 07/2014

REFERENCES

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2000. PMID:15130.

Allard JP, Royall D, Kurian R, Muggli R, Jeejeebhoy KN. Effects of beta-carotene supplementation on lipid

peroxidation in humans. Am J Clin Nutr 1994;59:884-90.

Baron JA, Cole BF, Mott L, et al. Neoplastic and antineoplastic effects of beta-carotene on colorectal adenoma

recurrence: results of a randomized trial. J Natl Cancer Inst 2003;95(10):717-722.

Bendich A. Beta-carotene and the immune response. Proc Nutr Soc 1991;50:263-74.

Bertram JS. Carotenoids and gene regulation. Nutr Rev 1999;57:182-91.

Buring JE, Hennekens CH. beta-carotene and cancer chemoprevention. J Cell Biochem Suppl 1995;22:226-

30.

Christen WG, Manson JE, Glynn RJ, et al. Beta carotene supplementation and age-related maculopathy in a

randomized trial of US physicians. Arch Ophthalmol 2007 Mar;125(3):333-9.

Comstock GW, Burke AE, Hoffman SC, Helzlsouer KJ, Bendich A,Masi AT, Norkus EP, Malamet RL,

Gershwin ME. Serum

concentrations of alpha tocopherol, beta carotene, and retinol preceding

the diagnosis of rheumatoid arthritis and systemic lupus erythematosus.

Ann Rheum Dis 1997;56:323-5. Cooper DA, Eldridge AL, Peters JC. Dietary carotenoids and certain cancers,

heart disease, and age-related macular degeneration: a review

of recent research. Nutr Rev 1999;57:201-14.

Daudu PA, Kelley DS, Taylor PC, Burri BJ, Wu MM. Effect of a low beta-carotene diet on the immune functions

of adult women. Am J Clin Nutr 1994;60:969-72.

Gey KF, Moser UK, Jordan P, Stahelin HB, Eichholzer M, Ludin E.Increased risk of cardiovascular disease at

suboptimal plasma

concentrations of essential antioxidants: an epidemiological update with special attention to carotene and

vitamin C. Am J Clin Nutr 1993;57:787S-797S.

Grodstein F, Kang JH, Glynn RJ, et al. A randomized trial of beta carotene supplementation and cognitive

function in men: the Physicians' Health Study II. Arch Intern Med 2007 Nov 12;167(20):2184-90.

Hennekens CH, Buring JE, Manson JE, Stampfer M, Rosner B, Cook NR, Belanger C, LaMotte F, Gaziano

JM, Ridker PM, Willett W, Peto

R. Lack of effect of long-term supplementation with beta carotene on

the incidence of malignant neoplasms and cardiovascular disease [see

comments]. N Engl J Med 1996;334:1145-9.

Herraiz LA, Hsieh WC, Parker RS, Swanson JE, Bendich A, Roe DA. Effect of UV exposure and beta-carotene

supplementation on delayedtype

hypersensitivity response in healthy older men. J Am Coll Nutr1998;17:617-24.

Kornhauser A, Wamer WG, Lambert LA, Wei RR. beta-Carotene inhibition of chemically induced toxicity in

vivo and in vitro. Food

Chem Toxicol 1994;32:149-54.

Krinsky NI. Carotenoids as antioxidants. Nutrition 2001 Oct;17(10):815-7 2001. PMID:15110.

Lambert LA, Wamer WG, Wei RR, Lavu S, Chirtel SJ, Kornhauser A.The protective but nonsynergistic effect of

dietary beta-carotene and vitamin E on skin tumorigenesis in Skh mice. Nutr Cancer 1994;21:1-12.

Levy Y, Zaltsberg H, Ben-Amotz A, Kanter Y, Aviram M. Dietary supplementation of a natural isomer mixture of

beta-carotene inhibits oxidation of LDL derived from patients with diabetes mellitus. Ann Nutr Metab.

2000;44(2):54-60.

Murata T, Tamai H, Morinobu T, Manago M, Takenaka H, Hayashi K,Mino M. Effect of long-term

administration of beta-carotene on

lymphocyte subsets in humans. Am J Clin Nutr 1994;60:597-602.

Nishino H. Cancer chemoprevention by natural carotenoids and their related compounds. J Cell Biochem

Suppl 1995;22:231-5.A-Potene™

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PRODUCT DATA DOUGLAS LABORATORIES® 07/2014

Noonan FP, Webber LJ, De Fabo EC, Hoffman HA, Bendich A,Mathews-Roth M. Dietary beta-carotene and

ultraviolet-induced immunosuppression. Clin Exp Immunol 1996;103:54-60.

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1995;19:575-81.

Santos MS, Leka LS, Ribaya-Mercado JD, Russell RM, Meydani M, Hennekens CH, Gaziano JM, Meydani

SN. Short- and long-term betacarotene supplementation do not influence T cell-mediated immunity in

healthy elderly persons. Am J Clin Nutr 1997;66:917-24.

Santos MS, Meydani SN, Leka L, Wu D, Fotouhi N, Meydani M, Hennekens CH, Gaziano JM. Natural killer cell

activity in elderly men

is enhanced by beta- carotene supplementation. Am J Clin Nutr

1996;64:772-7.

Teikari JM, Virtamo J, Rautalahti M, Palmgren J, Liesto K, Heinonen

OP. Long-term supplementation with alpha-tocopherol and betacarotene and age-related cataract. Acta

Ophthalmol Scand

1997;75:634-40.

Wamer WG, Wei RR, Matusik JE, Kornhauser A, Dunkel VC. beta-Carotene uptake, metabolism, and

distribution in vitro. Ann N Y Acad

Sci 1993;691:284-6.

Wei RR, Wamer WG, Lambert LA, Kornhauser A. beta-Caroteneuptake and effects on intracellular levels of

retinol in vitro. Nutr Cancer 1998;30:53-8.

Young AJ, Lowe GM. Antioxidant and prooxidant properties of carotenoids. Arch Biochem Biophys 2001 Jan

1;385(1):20-7 2001. PMID:15120

For more information on A-Potene™ visit douglaslabs.com

† These statements have not been evaluated by the Food and Drug Administration.

This product is not intended to diagnose, treat, cure, or prevent any disease.


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