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Glucoset

$25.96

INDICATIONS

Glucoset™ may be a useful dietary supplement for those who wish to support nutritional control of healthy

blood sugar metabolism.

FORMULA (#GST)

Two Vegetarian Capsules contain:

Thiamine (pyrophosphate) ........................................... 50Nmg.

Biotin ............................................................................ 2,500 mcg.

Chromium (ChromeMate® polynicotinate*) ................. 800 mcg.

Alpha-Lipoic Acid** ...................................................... 200 mg.

N-Acetyl-L-Cysteine ..................................................... 500 mg.

Gymnema sylvestre leaf, ............................................. 400 mg.

dried extract, 25% gymnemic acids

* ChromeMate® brand. U.S. Patent Number 4,923,855 InterHealth Co.

** Lipoic Acid used in this product is of the highest quality available and of Italian origin.

SUGGESTED USE

Two capsules, three times daily at the start of a meal, or as directed by physician.

SIDE EFFECTS

No adverse side effects have been reported.

STORAGE

Store in a cool, dry place, away from direct light. Keep out of reach of children.

REFERENCES

Anderson RA. Nutritional factors influencing the glucose/insulin system: chromium. J Am Coll Nutr

1997;16:404-10.

Anderson, RA. Chromium, glucose intolerance, and diabetes. J Am Coll Nutr 1998;17:548-55.

Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. J Ethnopharmacol

1990;30:295-300.

Bierhaus A, Chevion S, Chevion M, Hofmann M, et al. Advanced glycation end product-induced activation of

NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells. Diabetes 1997;46:1481-90.

Booth AA, Khalifah RG, Hudson BG. Thiamine pyrophosphate and pyridoxine inhibit the formation of antigenic

advanced glycation end-products: comparison with aminoguanidine. Biochem Biophys Res Commun

1996;220:113-9.

Chauhan J, Dakshinamurti K. Transcriptional regulation of the glucokinase gene by biotin in starved rats. J

Biol Chem 1991;266:10035-8.

Cunningham JJ. Micronutrients as nutriceutical interventions in diabetes mellitus. J Am Coll Nutr 1998;17:7-

10.

De Mattia G, Bravi MC, Laurenti O,Cassone-Faldetta M, et al. Reduction of oxidative stress by oral N-acetyl-Lcysteine

treatment decreases plasma soluble vascular cell adhesion molecule-1 concentrations in non-obese,

non-dyslipidaemic, normotensive, patients with non-insulin dependent diabetes. Diabetoliga 1998;41:1392-6.

Frye EB, Degenhardt TP, Thorpe SR, Baynes JW. Role of the Maillard reaction in aging of tissue proteins.

Advanced glycation end product-dependent increase in imidazolium cross-links in human lens proteins.

J Biol Chem 1998;273:18714-9.

Kaneto H, Fujii J, Myint T, et al. Reducing sugars trigger oxidative modification and apoptosis in pancreatic

beta-cells by provoking oxidative stress through the glycation reaction. Biochem J 1996;320:855-63.

Koutisikos D, Agroyannis B, Tzanatos-Exarchou H. Biotin for diabetic peripheral neuropathy. Biomed

Pharmacother 1990;44:511-4.

Levi B, Werman MJ. Long-term fructose consumption accelerates glycation and several age-related variables

in male rats. J Nutr 1998;128:1442-9.

Low PA, Nickander KK, Tritschler HJ. The roles of oxidative stress and antioxidant treatment in experimental

diabetic neuropathy. Diabetes 1997;46 Suppl 2:S38-42.

Mertz W. Chromium in human nutrition: a review. J Nutr 1993;123:626-33.

Obrosova I, Cao X, Greene DA, Stevens MJ. Diabetes-induced changes in lens antioxidant status, glucose

utilization and energy metabolism: effect of DL-alpha-lipoic acid. Diabetologia 1998;41:1442-50.

Okabayashi Y, Tani S, Fujisawa T, et al. Effect of Gymnema sylvestre, R.Br. on glucose homeostasis in rats.

Diabetes Res Clin Pract 1990;9:143-8.

Preuss HG. Effects of glucose/insulin pertubations on aging and chronic disorders of aging: the evidence. J

Am Coll Nutr 1997;16:397-403.

Shanmugasundaram ER, Rajeswari G, Baskaran K, et al. Use of Gymnema sylvestre leaf extract in the

control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol 1990;30:281-94.

Shanmugasundaram KR, Panneerselvam C, Samundram P, Shanmugasundaram ER. Enzyme changes and

glucose utilization in diabetic rabbits: the effect of Gymnema sylvestre, R. Br. J Ethnopharmacol 1983;7:205-

34.

Thorpe SR, Baynes JW. Role of the Maillard reaction in diabetes mellitus and diseases of aging. Drugs Aging

1996;9:69-77.

Yang CW, Vlassara H, Peten EP, et al. Advanced glycation end products up-regulate gene expression found

in diabetic glomerular disease. Proc Natl Acad Sci USA 1994;91:9436-40.

Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the

antioxidant alpha-lipoic acid. A 3-week multicentre randomised controlled trial (ALADIN Study). Diabetologia

1995;38:1425-33.

For more information on Glucoset™ visit douglaslabs.com

† These statements have not been evaluated by the Food and Drug Administration.

This product is not intended to diagnose, treat, cure, or prevent any disease

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